Foods To Avoid With Trulicity

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Lindsay Ewan, MD
Lindsay Ewan, MD
Dr. Lindsay Ann Ewan, MD is Chief Medical Officer at Ethics Advisors, LLC. She worked previously as a Assistant Professor of Pediatrics, Section of Adolescent Medicine, University of Oklahoma. She have done Masters in Public Health, University of South Florida and Doctor of Medicine from University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.

If you have Type 2 diabetes, then chances are, you have heard of Trulicity. This medication is increasingly popular among physicians, so it is possible your physician may discuss prescribing it for you.

Starting a new drug can be a cause of worry. You want to ensure that the drug has its maximum effect, and may wonder how your diet may affect its action. You may ask, “which foods do I avoid when taking Trulicity?”

The quick answer to that is to avoid foods with high sugar, high fat and refined carbohydrates. But why must these be avoided? And should they be stopped completely? Read on for the answers to these questions.

Foods to Avoid With Trulicity

Trulicity, or Dulaglutide, has no known food interactions. That means its effects will not be minimized by any food, and will not react with any food items to produce severe adverse effects. That being said, it is recommended to eat smaller portions of food when you are taking Trulicity.

This is related to the way this drug works. Dulaglutide works like GLP-1 (Glucagon-like-peptide 1), and so it is referred to as a GLP-1 agonist. GLP-1 is a chemical that is released from the L-cells in your gut.

Foods to Avoid With Trulicity

This chemical increases insulin secretion and decreases the rate at which food crosses the stomach. It also reduces appetite. This is why consuming excessive sugar may overcome the effects of Dulaglutide.

Dulaglutide may also cause nausea and vomiting at times. So, ingesting foods that cause nausea might add to its effects, making you feel worse.

Let’s take a look at a few foods you should avoid on Dulaglutide.

Foods Containing High Sugar

High sugary food is a big no-no for any diabetic. Even if you are properly taking your medications, you should still not eat too many sugary foods.

If you are suffering from Type 2 diabetes, then there is insulin resistance in your body, meaning your pancreas has to work extra hard to secrete more insulin. Dulaglutide can help your pancreas in releasing more insulin.

However, too much sugar would overwork your pancreas, and in time, damage the pancreas. A damaged pancreas would make hyperglycemia harder to treat.

Foods With High-Fat Content

Fatty foods interfere with Trulicity in two possible ways. First, research shows that excessive fatty food intake reduces the levels of GLP-1 in your blood. This reduces the effect of Dulaglutide.

Secondly, these foods tend to cause nausea. Since Dulaglutide may also cause nausea, a high-fat meal could compound this discomfort.

Foods Containing Refined Carbohydrates

Refined carbohydrates cause the biggest spike in blood sugar levels. Research shows that excessive refined carbohydrate does not cause a proportionate increase in GLP-1 levels, which means that they are absorbed very quickly.

The pancreas may not be able to keep up with the high blood sugar in the bloodstream. Lower GLP-1 levels compared to the high calories consumed means that Trulicity may not be able to cause a large enough insulin release. This results in higher glucose levels.

Related Article: Trulicity for weight loss: Side effects, dosages, uses, and more

Drinks to Avoid with Trulicity

What about drinks to avoid with Trulicity? As expected, you should not consume drinks that contain excess sugar. It causes the same reaction as sugary foods explained above. Soda, energy drinks, sports drinks and artificial fruit drinks are examples of sugary drinks to avoid. Still, you do not have to give them up completely; small amounts will not do much harm.

Can you Drink Alcohol with Trulicity?

Alcohol be avoided while taking Trulicity. Alcohol is known to cause hypoglycemia. This is a clinical condition where your blood glucose is too low. It hampers the ability of the liver to produce sugar, lowering glucose levels in the bloodstream.

While Duraglutide is low risk when it comes to hypoglycemia compared to other drugs, it can increase your insulin levels. Insulin ultimately causes hypoglycemia, and Dulaglutide can further lower the already low blood sugar caused by alcohol.

Foods To Avoid With Trulicity

You do not have to completely stop alcohol. This is true if your diabetes is well-controlled and you have been taking Trulicity for quite some time. Mild amounts of alcohol will not cause too much trouble in that case.

Can you Drink Coffee with Trulicity?

The short answer is, yes, you can drink coffee with Trulicity. Caffeine does not interact with Trulicity in any way. But, if you add too much sugar and creamer, then that might be a problem.

Excessive caffeine might be harmful, as it has been proven to cause either hyperglycemia and hypoglycemia. Moderate amounts of coffee is harmless, especially where diabetes is well-controlled.

Can You Take Trulicity with Diabetic Medications?

You should always follow your doctor’s orders when taking medication. Your doctor may prescribe Trulicity with other diabetic medications. This drug has no adverse interactions with other diabetic medications.

You should never take antidiabetic drugs on your own without a physician’s prescription. This is because antidiabetic drugs do essentially one thing-decrease your blood glucose.

If you add other drugs on your own, you risk hypoglycemia. This can lead to severe problems in your body including brain damage.

The only drugs with which Trulicity has severe reactions are bexarotene and gatifloxacin. None of these drugs are antidiabetic medications.

Let’s look at some common queries about drug combinations with Trulicity.

Can You Take Trulicity with Victoza

The generic name of Victoza is Liraglutide. Liraglutide is also a GLP-1 agonist, just like Dulaglutide. It is unlikely that your doctor will prescribe both at the same time.

Your doctor may tell you to swap one with the other if one is not working. Taking both at the same time is uncommon.

Can You Take Trulicity with Metformin

You can take Trulicity and Metformin together. There are no adverse reactions. However, you should take it only with the doctor’s advice. That is because the doses have to be adjusted together.

Can You Take Trulicity with Insulin

You can take Trulicity with Insulin if your doctor suggests it. Trulicity does not interact directly with insulin. Both of these drugs can lower blood sugar, so the dosage is critically important and should be monitored by your physician.

Can You Take Trulicity with Jardiance

You can take Trulicity with Jardiance per a physician’s advice. Jardiance or empagliflozin is an SGLT-2 inhibitor, which means it lowers blood sugar by increasing its excretion from the body. It may also cause hypoglycemia, so the dosage adjustment by a physician is necessary.

Can You Take Trulicity with Tradjenta

You can take Trulicity with Tradjenta. This drug is an incretin modifier type of drug, which means it increases insulin secretion. Tradjenta may cause hypoglycemia, but it does not directly interact with Trulicty. These medications can be combined if their doses are adjusted by a physician.

What Should You Eat While Taking Trulicity

As mentioned above, Trulicity does not interact with any food directly. But it is best to stick to the diabetic diet. That way, Trulicity can work effectively to check your blood glucose. Below are some foods that you can try incorporating into your diet.

Foods Rich In Vitamins

Vitamins and antioxidants are essential for your body in small amounts. Deficiencies of vitamins can cause harm to your body. Vitamin-rich foods include fresh fruits, vegetables, milk, and liver.

Foods Rich In Fiber and Complex Carbohydrates

Complex carbohydrates and fibers are the best sources of carbohydrates for diabetics. These are broken down and absorbed slowly. They do not cause a spike in blood glucose, which helps Trulicity to work effectively. Fibers and complex carbohydrates include whole grains, apples, beans, cabbage, celery, kale, beans, and broccoli.

Foods Rich in Antioxidants

Antioxidants are compounds that can fight against free radicals. Free radicals are responsible for harm to your body. Diabetic patients often have fewer antioxidants in their bodies. Taking antioxidant-rich foods like carrots, watermelon, squash, papaya, strawberries, etc. is helpful.

Foods With Healthy Fats like Omega-3 Fatty Acids

Healthy fats help diabetics with their insulin resistance. Healthy fats can be found in avocado, coconut, sea fish oil, nuts, seeds, olive oil, and palm oil.

Should I Take Trulicity with Food

Food does not interfere with Trulicity’s actions, so it does not matter if you take it with or without food.

Can you Take Trulicity On an Empty Stomach?

Yes, you can take Trulicity on an empty stomach. This drug is given as an injection, so it can not cause stomach upset due to an empty stomach.

Can you Take Trulicity after Eating?

Yes, you can take Trulicity after eating. This drug is given as an injection, so food in the stomach will not interfere with its absorption.

How Long Does Trulicity Stay In Your System?

Trulicity may stay in your system for 25-30 days.

Trulicity has a half-life of around 5 days for most individuals. Half-life means the amount of time your body takes to push half of the drug out of the body. It takes 5 to 6 half-lives for your body to completely eliminate any drug (i.e., 25-30 days for Trulicity).

Side Effects of Trulicity

Like all other drugs, Trulicity has its own share of side effects. Most are not serious. However, in rare cases, a few serious side effects have been noted.

Stomach Problems

Gastrointestinal issues are the most common side effects of Trulicity. Symptoms such as nausea, vomiting, diarrhea, and anorexia may occur, but not severely.

Acute Pancreatitis

This is a rare but serious side effect of Trulicity. Acute pancreatitis presents with severe central abdominal pain. This pain radiates to the back and is relieved by leaning forward.

Low Blood Sugar

Although less than other diabetic drugs, Trulicity can still cause hypoglycemia. Symptoms of hypoglycemia include palpitations, sweating, dizziness, and loss of vision.

Allergic Reactions

Because it is given by subcutaneous injection, there can be dermal and/or systemic allergic reactions as well. Allergic symptoms may include rash, hives, itching, swelling, breathing difficulty, and palpitations.

Acute Kidney Injury

Like other GLP-1 agonists, Dulaglutide may cause kidney injury. This manifests as sudden stoppage of urine, fatigue, and muscle cramps.

Gallbladder Problems

Trulicity increases the risk of cholecystitis. This causes pain in the upper right abdomen and right shoulder that increases with fatty food.


Dulaglutide increases the risk of thyroid gland tumors. If you notice any abnormal neck swellings, inform your doctor immediately.

How To Avoid Trulicity Side Effects

If you notice any new symptoms after starting Trulicity, you should inform your doctor immediately. Your physician may need to adjust your dose or switch up your medications.

You should not take more than the prescribed amount.

Solution: Pancreas Inflammation

Reducing your alcohol intake can decrease the chance of pancreatitis.

Solution: Allergic Reaction

For an allergic reaction, you need to stop the drug and inform your doctor. They can administer the proper medication to treat the reaction.

Solution: Digestive Problems

The proper antiemetic drugs can reduce this problem if it becomes too severe.

Solution: Low Blood Sugar

If you feel the symptoms of low blood sugar, then you can consume anything sweet, like candy.


Are There Any Generic Substitutes for Trulicity?

There are no other generic substitutes for Dulaglutide or Trulicity. But there are other cheaper antidiabetic drugs that your doctor may suggest at your request.

Should Trulicity be stored at room temperature?

Trulicity can be stored at room temperature for up to 2 weeks. For longer storage time, refrigeration is recommended. Take care to not freeze it.

What is the best time of day to inject Trulicity?

You can take Trulicity at any time of the day. Additionally, it does not matter whether you take it on an empty stomach.


Trulicity works best when it is taken as prescribed by a physician. Avoiding food and drink that are high in fat and sugar helps control blood glucose levels. This will make it easier for Dulaglutide to exert its effect and help you live a longer healthier life.

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